Heat-stable liposomes from milk fat globule membrane phospholipids for pH-triggered delivery of hydrophilic and lipophilic bioactives

Heat-stable, multivitamin-loaded, and surface-coated liposomes tailored for pH-triggered delivery of both lipophilic hydrophilic bioactives were synthesized from a cocktail milk fat globule membrane (MFGM) phospholipids, supercritically extracted buttermilk powder. Liposomes MFGM-phospholipids (ML) fabricated using novel organic solvent free process based on venturi-based rapid expansion supercritical solution. A commercially available pH-responsive polymer, Eudragit® S100 was used to coat ML (Eu-ML). Eu-MLs heated 60, 75, 90 °C 30 min observed be heat-stable as established by CLSM images, structural characterizations, encapsulation efficiency measurements. Coating with protected encapsulated payload deleterious gastric environment facilitated site-specific release in the simulated intestinal condition. This study green method fabricate liposomal vehicles bioactive compounds excellent potential scale-up applications food, pharmaceutical, cosmetic industries.